Types of Muscular Dystrophy and Neuromuscular Diseases

Becker

Teen to early adulthood

Symptoms are almost the same as Duchenne, but less severe. It progresses more slowly than Duchenne. Survival goes into middle age. Becker disease is almost always limited to males. This is the same as with Duchenne.

Congenital

Birth

Symptoms include general muscle weakness and possible joint deformities. The disease progresses slowly. It causes a shortened life span.

Duchenne

Ages 2 to 6

Symptoms include general muscle weakness and wasting. It affects the pelvis, upper arms, and upper legs. Over time, it includes all voluntary muscles. Survival beyond the 20s is rare. It happens mostly in boys. Very rarely it can affect women, who have much milder symptoms and a better prognosis.

Distal

Ages 40 to 60

Symptoms include weakness and wasting of muscles of the hands, forearms, and lower legs. Progression is slow. It rarely leads to total disability.

Emery-Dreifuss

Childhood to early teens

Symptoms include weakness and wasting of shoulder, upper arm, and shin muscles. Joint deformities are common. progression is slow. Sudden death may occur from cardiac problems.

Facioscapulohumeral

Childhood to early adults

Symptoms include facial muscle weakness and weakness with some wasting of shoulders and upper arms. Progression is slow with periods of rapid deterioration. Life span may be many decades after onset.

Limb-Girdle

Late childhood to middle age

Symptoms include weakness and wasting, affecting shoulder girdle and pelvic girdle first. Progression is slow. Death is usually due to cardiopulmonary complications.

Myotonic

Ages 20 to 40

Symptoms include weakness of all muscle groups and delayed relaxation of muscles after contraction. It affects the face, feet, hands, and neck first. Progression is slow, sometimes spanning 50 to 60 years. An infantile form causes more severe problems.

Oculopharyngeal

Ages 40 to 70

Symptoms affect muscles of eyelids and throat causing weakening of throat muscles. Over time, this causes inability to swallow and severe weight loss from lack of food. Progression is slow.

Motor neuron diseases:

• Amyotrophic lateral sclerosis, or motor neuron disease

• Infantile progressive spinal muscular atrophy

• Intermediate spinal muscular atrophy

• Juvenile spinal muscular atrophy

• Adult spinal muscular atrophy

• Progressive muscular atrophy

• Infectious myelitis (polio, West Nile)

Inflammatory myopathies:

• Dermatomyositis

• Polymyositis

• Inclusion body myositis

Diseases of peripheral nerve:

• Charcot-Marie-Tooth disease

• Dejerine-Sottas disease

• Friedreich's ataxia

• Toxic neuropathy

• Neuropathy due to medical disease (such as diabetes, kidney disease, or cancer)

Diseases of the neuromuscular junction:

• Myasthenia gravis

• Lambert-Eaton syndrome

• Botulism

Metabolic diseases of the muscle:

• Acid maltase deficiency

• Carnitine deficiency

• Carnitine palmityl transferase deficiency

• Debrancher enzyme deficiency

• Lactate dehydrogenase deficiency

• Mitochondrial myopathy

• Myoadenylate deaminase deficiency

• Phosphorylase deficiency

• Phosphofructokinase deficiency

• Phosphoglycerate kinase deficiency

Less common myopathies:

• Central core disease

• Hyperthyroid myopathy

• Myotonia congenita

• Myotubular myopathy

• Nemaline myopathy

• Paramyotonia congenita

• Periodic paralysis-hypokalemic-hyperkalemic