Dismiss Modal

Definition

Anatomy of the Stomach

Choose a preferred language

The stomach is a J-shaped organ in the upper belly (abdomen). It’s part of the digestive system. It’s between the end of the food pipe (esophagus) and the start of the first part of the small bowel (duodenum).

Front view of woman showing esophagus, stomach, and duodenum.

The stomach is much like a bag with a lining. The stomach is made of these five layers:

  • Mucosa. This is the first and innermost layer or lining. It contains the glands that release digestive juices. These are called hydrochloric acid and pepsin. This is where most stomach cancers start.

  • Submucosa. This second layer supports the mucosa. It is rich in blood vessels, lymphatic vessels, and nerves.

  • Muscularis. The third layer is made of thick muscles. They help to mix food with the digestive juices.

  • Subserosa. This layer contains supporting tissues for the serosa.

  • Serosa. This is the last and outermost layer. It’s the lining that wraps around the stomach to confine it.

After you chew and swallow food, it enters your stomach from the food pipe (esophagus). At this point, pepsin and hydrochloric acid are released. Your stomach muscles create a rippling motion, which combines the food with the digestive juices. After about 2 to 3 hours, partly digested food moves into the small intestine. This is where it’s broken down further, and over time, nutrients are absorbed into your body.

© 2025 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare provider's instructions.
stethoscope icon

Personalized care starts with the right provider

Search by specialty, location, and more.

FIND A DOCTOR
Related Articles
Read article
Digestive Health
Gallbladder Cancer: Stages

The stage of a cancer is how much and how far the cancer has spread in your body. It is one of the most important things to know when deciding how to treat the cancer.

Read article
Digestive Health
Laryngeal Cancer: Stages

The stage of a cancer is how much and how far the cancer has spread in your body. The stage of a cancer is one of the most important things to know when deciding how to treat the cancer.

Read article
Digestive Health
Pancreatic Cancer: Newly Diagnosed

Being told you have pancreatic cancer can be scary, and you may have many questions. But you have people on your healthcare team to help.

Read article
Digestive Health
Liver Cancer: Newly Diagnosed

Being told you have liver cancer can be scary, and you may have many questions. But you have people on your healthcare team to help.